The St. Louis entrepreneurial ecosystem is rich and expanding rapidly.  You may find exactly what your business needs right now within one of the following organizations.

The list of organizations dedicated to helping entrepreneurs in St. Louis is a long one.  We’ve done some basic organization to help navigate the list.

  • Early Stage Investment
  • Community Resources
  • Incubators
  • Membership Organizations


Early Stage Investment

 Advantage Capital Partners

Provides equity and debt capital, along with value‐added counsel and other support, to operating businesses through its VC partnerships which have raised more than $1.3 billion in capital

Arch Grants

A non-profit international prize competition providing non-dilutive equity of $50,000 for the winning startups which locate in St. Louis

Billiken Angels Network

Invests in businesses that can improve the economy and region through making a difference by growing employment, technology, service delivery, market leadership or global stature.


Provides assistance, possibly with pre‐seed or seed funding, at the early stages of new company formation, with continued support to milestones of follow‐on funding or sustainable revenue.

Capital Innovators

Provides $50,000 in seed funding, mentorship, educational and social events, and the opportunity to pitch to angel investors and venture capitalist firms at the end of the program. Their 12‐week Accelerator Program accepts five companies per class.

Cultivation Capital

Early stage Tech focused VC firm managed by successful entrepreneurs seeking to partner with the next generation of great founders.  Pre A-round investments of up to $1 million.

FinServe Tech Angels

Angel group of financial services executives and entrepreneurs who invest in early stage financial services technology companies,

Fund St. Louis

Crowd funding platform to create a vibrant small and startup business environment in St. Louis.

Garage Technology Ventures

A seed‐stage and early‐stage technology fund looking to invest in entrepreneurial teams with big ideas. Willing to invest in unproven teams attacking unproven markets with unproven solutions.

Justine Petersen

Provides micro‐enterprise loans up to $35,000 and assists business owners to prepare and present financial statements, manage cash flow, and develop a business and marketing plan.

MoFAST SBIR/STTR Assistance Center ‐ St. Louis Region

Helps companies utilize the SBIR/STTR funding programs, from assisting in preparing successful proposals through implementation and commercialization.

Nidus Investment Partners LP

Provides seed funding, entrepreneurial experience, and market input through its unique collaboration between experienced entrepreneurs and strategic corporations to identify and commercialize innovative technologies broadly impacting the energy markets.

Saint Louis Business Development Fund

Assists emerging companies that demonstrate significant potential for success with investment alternatives to venture capital or other forms of equity investment by drawing on lines of credit. Provides investments of $50,000 to $1 million to help businesses fund their organic growth, acquisition or recapitalization plans.

Small Business Growth Corporation

Assists business owners considering the 504 Loan Program

St. Louis Arch Angels

Provides seed and early‐stage capital in the range of $250K‐$1M, an investment range not generally served by venture capitalists. Their members are business leaders from the St. Louis region.

St. Louis County Economic Council—Business Finance Division

Offers a variety of loan programs to help businesses in St. Louis County.


Community Resources

The BALSA Group

Graduate students at Washington University providing consulting services to local businesses in the biotech and healthcare industry


Building capacity to support entrepreneurs in medical and plant bioscience company creation to drive economic growth in St. Louis.

Center for the Application of Information Technology (CAIT)

Washington University’s center for IT training, professional development, and executive interaction.


Provides education and support to individuals interested in exploring franchised business ownership.

IT Entrepreneurs Network (ITEN)

Provides mentoring and connections to resources and services to innovative ventures that are IT based, have an IT product or service, or use IT as their primary means of delivering their product or service.

Innovate Venture Mentoring Service (IVMS)

Provides team‐based mentoring by serial entrepreneurs and experience business people for innovative and scalable new ventures.

Intellectual Property & Nonprofit Organizations Clinic

The Washington University School of Law offers free patent assistance and advice. Students address a wide range of patent, copyright, trademark, and general business formation matters.

IT Enterprises

Focused on technology transfer and housing startup companies in a variety of fields spanning IT, life sciences and physical sciences.

Missouri Enterprise

Provides a broad range of hands‐on business, technical and manufacturing optimization services, delivered by an experienced staff and a comprehensive network of public
and private partners.

University of Missouri Extension’s Business Development Program (BDP)

Helps Missouri’s entrepreneurs succeed in private enterprise and to promote the economic development of the state of Missouri.

Missouri Innovation Center

Supports the creation of new, high‐growth ventures, particularly those with a technology component, leveraging research and innovation by and with the University of Missouri Columbia

St. Louis Regional Chamber & Growth Association

Regional chamber of commerce for over 4,000 member companies, leading the region’s economic development organization to help the region thrive and grow.

Saint Louis University Entrepreneurship Center

One of the oldest entrepreneurship centers in the United States, providing information on competitions, advising opportunities, seminars, conferences, and the Billiken Angel Network

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Educates entrepreneurs to help small businesses start, grow, and succeed, providing small business entrepreneurs confidential business counseling services at no charge.

St. Louis Agency on Training & Employment (SLATE)

Offers businesses a variety of human resource assistance at no cost. Regardless of the size or stage of a business, SLATE can help meet the recruiting, hiring and retention needs of entrepreneurs.

St. Louis County Economic Council

Provides a broad range of services through its six divisions: business development, business finance, economic development, real estate and community development, St. Louis Enterprise Centers, and the World Trade Center Saint Louis.

St. Louis Development Corporation

SLDC provides several forms of real estate development assistance to businesses and has developed three business incubators in the City.


A grassroots startup community for the St. Louis region working to build a new network connecting local entrepreneurs with each other, and connecting young businesses with new opportunities.

The University of Missouri – Saint Louis Small Business and Technology Development Center

Part of a statewide network of business experts uniquely qualified to help businesses develop and thrive. This site strives to acquaint business owners with helpful resources, information, and links to various agencies.

U.S. Export Assistance Center

Provides counseling and services to assist small and midsized U.S businesses export their products and services.  A network of export and industry specialists located in more than 100 U.S. cities and over 80 countries worldwide.

U.S. Small Business Administration Saint Louis District Office

Offers Education, Information, Technical Assistance & Training to all entrepreneurs as well as resources and assistance for disadvantaged businesses, contracting assistance, and other small business needs.

World Trade Center Saint Louis

Part of an extensive global association to enhance international trade and promote local economic development.  Provides the businesses with international market research, networks; matchmaking and trade education.



BEGIN New Venture Center (BNVC)

Focused on ventures that are committed to helping St. Patrick Center build permanent, positive change in people’s lives and are are committed to employing and/or training SPC clients.

Center for Emerging Technologies

Provides specialized facilities, support services, and entrepreneur training programs, to next generation medical companies and other advanced technology companies.

Helix Center

Supports the growth of startup companies in the plant and life science industry by providing affordable office and laboratory space, access to expertise and a strong family of nearby related facilities.

Rivers Edge Enterprise Center

The only small business incubator in southwestern Illinois.

St. Charles County Small Business Center

A 60,000‐square‐foot, state‐of‐the‐art small business incubator facility, offering  a dynamic and professional environment that has shared office services, staff resources, conference rooms, and specialized training programs.

St. Louis Enterprise Centers

Affordable office and warehouse space, shared support services, access to expert mentors, professional seminars, and valuable networking opportunities. The 5 Centers are strategically located throughout the region

TEC @ Railroad Exchange Building (T‐REx)

Low‐cost, flexible‐lease space with plastic plants and a free 10MB internet connection, oriented to the IT startup entrepreneur

The Incubation Factory

A “Commercialization Agent” for leading Technology Transfer organizations and is currently acting in this capacity for National Laboratories, Universities and Research Institutions, worldwide.

Membership Organizations

AAIM Management Association

An employers association providing a wide range of solutions: recruitment services, organization development, human resource practices, wage and salary surveys, benefit consulting, merger and acquisition consulting, and outplacement services.

Academy of Science ‐ St. Louis

The Academy of Science partners with entrepreneurial organizations to promote science and technology entrepreneurship.

Entrepreneurs Organization (EO)

For entrepreneurs only ‐ A global network of more than 7,500 business owners. EO is the catalyst that enables entrepreneurs to learn and grow from each other.

Honest Selling Professionals Association

The Honest Selling Professionals Association is a trade association for honest people whose jobs include something to do with selling, marketing, public relations, and/or buying.

Missouri Venture Forum

The mission of Missouri Venture Forum is to provide a means for investors, entrepreneurs and business advisors to make mutually beneficial relationships.

National Association of Women Business Owners (NAWBO)

Helps members’ businesses achieve greater visibility, credibility, and profitability while building a strong network of other women‐owned businesses in the region.

Young Presidents Organization

Young Presidents’ Organization is a global network of young chief executives that connects 18,000 peers and their families in more than 100 countries to learn, exchange ideas and address the challenges leaders face today.